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Glucocorticoid receptor signalling pathways may be modified during stress through crosstalk with other stress-regulated pathways, indicating that the dynamics of the regulation of adult neurogenesis by stress are highly complex

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Highdose IV protocols (5001,500 mg daily for ~10 days) have been used in openlabel studies for substance use disorder, with reports of reduced cravings and improved mood in followups [2] [9]