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Ghasemian M, Owlia S, Owlia MB

Moreover, exendin-4 inhibits NF-B activity by hindering the breakdown of IB (NF-kappa-B inhibitor alpha) in LPS-stimulated primary microglia, which reduces the activation of microglia and the generation of pro-inflammatory cytokines [113]

2.4%) (Table 2)

Conclusion In light of the recent advances in our understanding of intra-islet GLP-1 biology, alpha- to beta-cell bidirectional paracrine signaling is increasingly recognized as a key contributor to whole-body metabolic function