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One more study indicates that upregulation of PTEN by MCR1 activation and inhibition of cyclooxygenase and prostaglandin E2 by melanotan II cause suppression of melanoma [10]

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Current research efforts are primarily concentrated on three strategic fronts: natural products, nano-drug delivery systems (NDDS), and combination chemo-/radiotherapy regimens, all aimed at potentiating ferroptosis induction and overcoming tumor resistance

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The relative optical density ratio was calculated by comparison to -actin