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Using the Caco2 monolayer assay, 7,8-DHF was found to be subject to various influx and efflux transporters, including P-glycoprotein (P-gp) and organic anion transporting polypeptides (OATPs) ( p,uu,brain ) ratio may need to be experimentally determined ( p estimation, with a 10% relative difference

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According to the experimental requirements, the mixture was cultured with or without COM in a conventional incubator for 24 h and then tested

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