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circMAP3K4 is another potentially important circRNA involved in glucose metabolism that is highly expressed in the placentas of patients with gestational diabetes mellitus (GDM) and the IR model

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Thus, activation of NFB by ROS (or other signaling pathways) upregulates the expression and activity of ROS generators, such as NADPH oxidase 1 and 2 (NOX1 and NOX2) that produce superoxide [9, 10]

doi: 10.1080/10715762.2019.1612891 151 JrvinenEIsmailKMuniandyMBoglLHeinonenSTummersMet al

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Potential Benefits Cellular energy (preclinical): Restoring NAD+ pools is reported to support mitochondrial function and energy metabolism in laboratory models [5] [6]