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or vector control (mock)

PTEN, mutated in multiple advanced cancers 1

After confirming that our siRNA sequences could effectively inhibit BACE1 mRNA (by 91%) and protein expression (by 76%) in mouse Neuro-2 cells, we tested the effects of siRNA-loaded ITP-modified lipid nanoparticles (ITP-LNPs/siRNAs) in APP/PS1 mice (Supplementary Figs

279 Pasricha, S

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