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Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature

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In ovaries, it modifies follicular support, endometrial repair, and local cytokine balance

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BBB dysfunction is associated with long COVID-induced cognitive impairment Given the significantly increased serum concentrations of S100, our data indicated that active and acute SARS-CoV-2 infection is associated with potential BBB dysfunction in individuals with neurological impairment

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