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AngII infusion also led to a significant heart rate increase during the first week and at the end of the 14-day treatment in vehicle-treated animals (see Supplementary Table 4.)

GIP activation enhances the brains internal garbage disposal system (autophagy), helping to clear out these toxic plaques before they can suffocate healthy tissue

Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S

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When compared to their isogenic controls, AD organoids showed a downregulation of a cluster of genes which included MAP1LC3A , ACSL6 , GCH1 , PRNP , among others (Fig