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[2] Additionally, GLP-1 agonists have been shown to reduce markers of systemic inflammation, including C-reactive protein (CRP), in patients with type 2 diabetes and cardiovascular disease, though these reductions are often modest
Similarly, cisplatin, a chemotherapy chemical, caused toxic complications of autophagy and cell death in mouse renal tubular epithelial EpiCM-a cells through ERK1/2 activation, whereas aristolochic acid I attenuated cell apoptosis through pERK1/2-mediated autophagy activation in rat RTCs (NRK-52E) 41
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Therefore, LDL particles have both a causal and a cumulative effect on the risk of ASCVDs [14]
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