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Pediatr Res 79:278286
Trial landscape and extent Registries show numerous small, largely early-phase trials across indications and routes (oral/liposomal, intranasal, IV, topical), including completed intranasal and oral cosmetic studies, PK/feasibility studies, and a terminated autism trial
The results were significant: At 48 weeks, participants receiving the 12 mg dose achieved a mean weight reduction of 24.2% (approximately 58 pounds or 26.2 kg) 100% of participants on the 8 mg or 12 mg doses lost at least 5% of their body weight More than 90% of participants on the 12 mg dose lost at least 10% of their body weight Nearly half of participants on the highest dose lost 25% or more of their body weight The study also showed improvements in cardiometabolic markers including blood pressure, triglycerides, LDL cholesterol, and fasting glucose
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