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Patients with active malignancy, pituitary pathology, or uncontrolled diabetes represent populations requiring particularly careful clinical judgment

Typically the first place to exhibit the signs of aging is the delicate skin around the eye, from crows feet to under-eye bags

Although RSL3 and ML162 were first described as direct GPX4 inhibitors [9, 48], several publications recently challenged this notion [49, 50]

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Some of the natural non-enzymatic antioxidants found in skin to help neutralize the free radicals are L-ascorbic (vitamin C), alpha-tocopherol (vitamin E), beta-carotene, uric acid, Co-Q-ten, and glutathione