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Patients should be educated about serious adverse effects requiring immediate medical attention, including: Pancreatitis: severe abdominal pain radiating to the back, persistent vomiting Hypersensitivity reactions: rash, difficulty breathing, facial swelling Gallbladder disease: right upper quadrant pain, fever, jaundice Thyroid C-cell tumors (boxed warning): neck mass, dysphagia, hoarseness, persistent dyspnea Regular follow-up with healthcare providers ensures appropriate monitoring and timely intervention if adverse effects occur
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Assays to evaluate payload release with different linkers in WuXi AppTec DMPK Figure 15
