Average weight loss appears greater with retatrutide in early studies, but individual response depends heavily on genetics and baseline metabolic function
It is the first medication to meaningfully address both sides of the energy balance equation: | Medication | What It Reduces | What It Burns | Max Weight Loss | |-----------|----------------|---------------|-----------------| | Semaglutide | Appetite (GLP-1) | -- | ~15-17% | | Tirzepatide | Appetite (GIP + GLP-1) | Minimal | ~20-22% | | **Retatrutide** | **Appetite (GIP + GLP-1)** | **Calories (Glucagon)** | **~24%** | That additional glucagon column is why retatrutide achieved more weight loss in less time than either competitor
Oxidative stress has been implicated in diseases such as cancer, arthritis, nonalcoholic fatty liver disease and diabetes
PMID: 15655171
Tan WC, Lo C, Jong A, Xing L, Fitzgerald MJ, Vollmer WM, Buist SA, Sin DD
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