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It might be the dose, the titration speed, a concurrent medication, an underlying condition, or a shift to a different GLP-1 medication entirely (tirzepatide, for instance, shows stronger average weight loss in head-to-head comparisons)

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The guidelines for upper arm injections are a bit more specific: Inject into the side or back of your upper arm Avoid the inner arm The semaglutide injection site should be at least 3 inches below your shoulder and 3 inches above your elbow

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The improvement in ankle-brachial index (ABI) with semaglutide seen in STRIDE suggests that GLP-1 receptor agonists directly modulate vascular structure and function, both experts noted

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