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The association between the genes of the -glutamyl cycle and autistic disorder is not well studied, although recently a relatively large study using a pathway approach showed a three-SNP joint interaction effect for glutaredoxin, glutaredoxin 3 and cystathione lyase (OR = 3.78, 95% CI: 2.36, 6.04) as well as marginal associations for cystathione lyase, the gamma-glutamylcysteine synthetase, catalytic subunit and glutaredoxin 3 suggesting that variation in genes involved in counterbalancing oxidative stress may contribute to autism [94]

Chemosphere 303:135156

Experimental Gerontology vol

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Booth, S.L., Golly, I., Sacheck, J.M., Roubenoff, R., Dallal, G.E., Hamada, K