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So, if your vitamin B12 deficiency is due to an autoimmune disease in which your stomach doesn't make intrinsic factor, supplements might not work for you, and you will need injections

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Six patients with chronic progressive MS received massive doses of methyl vitamin B12

The above investigations suggest that Cd-toxicity can vary based on Cd-doses and/or Cd load to the exposed plants, wherein a very low concentration of Cd can be toxic and detrimentally influence plant developmental processes and productivity