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Hormonal influence: Estrogen, progesterone, and thyroid This is where the hormones part really comes in

Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations

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Regression of oral Kaposis sarcoma in a case of AIDS on Zidovudine (AZT)

Moreover, oxidative stress makes the kidney tissue susceptible to damage by various alterations including the promotion of lipid peroxidation, protein modification, and DNA damage, leading to cell death [14]