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Chapter 10

A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data

Toxicol Sci 42, 112

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It has been suggested that GLUD1 assumes in its basal state a configuration (open catalytic cleft) that permits catalytic activity regardless of whether the allosteric sites are functional

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