A brief spike in GLP-1 after taking a supplement is fundamentally different from the sustained, 24/7 receptor activation provided by weekly semaglutide injections
Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement
If youre asymptomatic, theres no reason to stop your GLP-1 medication, even if gallstones are present. However, when symptoms do appear especially pain or fever action is important
Iiri, T., Herzmark, P., Nakamoto, J
In this cell type, the effect of GLP-1(2836) on cAMP levels was as robust as that of the adrenergic agonist isoproterenol (IPE) (Figure 3A)
On paper, this sounds great