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People taking metformin and tirzepatide together may experience compounded GI effects that require extra attention to hydration

They come from different populations, different treatment durations, different placebo runs, and different statistical estimands (for example, the efficacy estimand that assumes continued treatment versus the treatment-regimen estimand that counts discontinuations)

People experiencing symptoms of DVT and PE should seek immediate medical care

If you're prone to heaviness, nausea, or reflux, a slower-digesting, thicker shake may feel like it sits in your stomach