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Patients on Tirzepatide 15 mg weekly lost an average of 20.9% or 48.6 lb of their body weight after 72 weeks in the Zepbound Study 1 (NCT04184622) compared to placebo patients who lost an average of 3.1% or 7.2 lb

It reported increased explant outgrowth, cell survival under stress and migration associated with FAK-paxillin signalling

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Sex was based on reporting by the parents or the adult study participants, with no selection restrictions applied in terms of regional and socioeconomic factors