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The safety profiled show that 36 patients (43.9%, 36/82) had adverse effects

Therefore, it is urgent to obtain potent ferroptosis inhibitors with good biocompatibility, strong stability and high safety by target-based or cell-based high-throughput screening, structural modification and other methods

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WD-fed StarD5 -/- mice up-regulated the transcriptional regulator Taz expression with accelerated liver fibrosis

The single dose, short (1 h) observation period, and lack of placebo arm are limitations in this proof-of-concept study and provide direction for follow-up studies

Published 1999