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Whereas a previous meta-analysis of seven RCTs ( n = 390) preliminarily suggested AID benefits for glycemic control, its limited sample size and methodological limitations in crossover trial analysis constrained validity and clinical interpretation [13]

Most studies achieve sustainable results from 3 months onwards

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One is to add a single compound at a time, so any change can be attributed to it

8 SUMMIT also demonstrated significant improvements in patient-reported outcomes: at 52 weeks, tirzepatide increased KCCQ-CSS, with a between-group mean difference of 6.9 points, and increased 6-minute walk distance, with a between-group mean difference of 18.3 m

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