The products appear well tolerated at doses up to 2000 mcg daily based on available reports
Wu YS, Osman AI, Hosny M, Elgarahy AM, Eltaweil AS, Rooney DW, Chen Z, Rahim NS, Sekar M, Gopinath SCB, Rani NNIM, Batumalaie K, Yap P (2024) The toxicity of mercury and its chemical compounds: molecular mechanisms and environmental and human health implications: a comprehensive review
Alternative medications include: TNF agents such etanercept (Enbrel), infliximab (Remicaide), or adalimumab (Humira) IL-17 agents such as secukinumab (Cosentyx) and ixekizumab (Taltz) Tofacitinib (Xeljanz) a JAK inhibitor (not approved by FDA yet but understudy) These biologic medications may alter the progression of disease by treating inflammation and preventing the development of fibrosis and then bone formation
For a beneficial liver detox, limit alcohol, ultra-processed products, excessive added sugars, sugary snacks, and repeated overly rich meals
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MMWR Morb Mortal Wkly Rep