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However, it is well documented in the art that the presence of three CDRs from the light chain variable domain and three CDRs from the heavy chain variable domain of an antibody is not necessary for antigen binding

Dose escalation is gradual to minimise gastrointestinal side effects such as nausea and vomiting

Girada, S.B

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Therefore, other anti-diabetic agents may be required to meet the therapeutic goals of glycated hemoglobin, which are recommended by several clinical guidelines 15,16

141,142 The Phase III clinical trials of tirzepatide were conducted in 77 research centers across seven countries, including the United States, Brazil, and Japan