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The efficacy and safety of the new pharmacotherapies after bariatric surgery require further investigation, however the benefits of GLP-1 RA after bariatric surgery on WL and glycaemia have been shown in clinical trials [103, 104]

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With FDA approval, resmetirom, a liver-targeted thyroid hormone receptor- (THR) selective agonist, changes the MASH drug development landscape

In this review, we focus on the actions of GLP-1RAs in the CNS, with emphasis on the contribution of GLP-1 to reset energy balance by promoting BAT recruitment

After 8 weeks of TAC, -MSH-treated mice showed attenuated LV hypertrophy compared to vehicle-treated TAC mice as evidenced by reduction in ventricular weight, ventricular weight-to-tibia length ratio (Fig