Carnitines role in brain health: Besides fertility, carnitine is implicated in brain plasticity and cognitive functions, with acetylcarnitine influencing gene expression through histone acetylation
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Briefly, the brain homogenate was diluted 1:20 (v:v) with ice-cold Lockes buffer (154 mM NaCcl, 5.6 mM KCl, 3.6 mM NaHCO3, 2.0 mM CaCl2, 10 mM D-glucose and 5 mM HEPES, pH 7.4) to obtain a concentration of 10 mg tissue/ml
After PSM, all standardized differences for the covariates were less than 0.1, indicating that a good balance was achieved (Table 1)
Wang L, Wu Z, Xu C, Ye H
Based on this publication, the conversion rate from rat to human doses is about 1:6.2