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However, discontinuation rates in Phase 2 were low (~6% at 12 mg), which suggests side effects were manageable for most participants

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Elastin degradation While collagen provides structural support, elastin provides snap-back, the ability of skin to return to its original position after stretching or compression

Post-inflammatory hyperpigmentation (PIH): This occurs after trauma or inflammation, such as acne, leading to dark marks where the skin has healed

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The widening of the indication from diabetes to cardiovascular diseases, obesity, sleep apnea, Alzheimer's, and kidney diseases is creating new opportunities for future growth