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In mouse models of DMD, it has been found that IGF1-LR3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis

Cell hyperplasia & GH/IGF-1 axis Explored in research on IGF-1 receptor signaling and hyperplasia

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In addition, chemokines play essential roles in driving Th2-skewed immune responses, disrupting skin barrier function, and amplifying downstream inflammatory signaling cascades (Kitahata et al., 2022)