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Alpha lipoic acid exists in two forms, S-Lipoic acid or R-Lipoic acid, the latter being the naturally occurring and more biologically active form found in the body.6 Results from one comparative study, recorded plasma concentrations of R-Lipoic acid were as much as 40-50% higher than S-Lipoic acid in volunteers who received a 600mg oral dose of each

Appelman B, Charlton BT, Goulding RP, Kerkhoff TJ, Breedveld EA, Noort W, et al

Ziegler, D., Nowak, H., Kempler, P., Vargha, P., & Low, P

The Phe residue that moves between the open and closed conformation is displayed in orange and the residue forming a hydrogen bond with the ligand is displayed in green

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