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Design : This was a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial for 72 weeks that included patients with biopsy confirmed NASH and hepatic fibrosis (stage F1, F2, or F3 but not F4/cirrhosis)
[8] [9] This sympathetic activation may be mediated through central nervous system pathways, as GLP-1 receptors are present in the hypothalamus and brainstem regions that regulate cardiovascular function
GLP-1 medicines acting through weight loss-dependent and weight loss-independent mechanisms hold potential for suppression of tumorigenesis and reduction of rates of obesity-associated cancer
To validate the protein network analysis and further characterize influenza-induced changes in metabolism, we quantified glucose, pyruvate, glutamine, and palmitic acid oxidation as previously described [14]
Further studies will be needed to confirm these preliminary results and test this supplement in older individuals with this condition