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M.AlonaziM.BhatR

Chronic granulomatous disease (CGD) is a syndrome that results in individuals harboring defects in the NOX2 form of the NADPH oxidase system

Twenty-three patients in 16 families with similar clinical manifestations and two mutations in the COQ6 gene have been identified to date [65-71]

BMP-2, for instance, engages the SMAD signaling pathway by binding to serine/threonine kinase receptors on the cell surface, resulting in the phosphorylation and translocation of SMAD proteins into the nucleus

Methods Animals We used 6-week-old male C57BL/6J mice (obtained from the Experimental Animal Center of Tongji Medical College, Huazhong University of Science and Technology) and 6-week-old male Nrf2 knockout mice (B6.129 1-Nfe2l2 tm1Ywk /J, purchased from Jackson Laboratory, Bar Harbor, ME) for the experiments

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