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The powder will not dissolve If gentle rolling for 10-15 minutes does not fully dissolve the powder, there are a few possibilities

The skin should be healthy, intact, and free of any of the following

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Keeping your thumb on the dose button, remove the needle from your skin

There are solid reasons to sit at a dose longer than four weeks or pause the climb entirely, and none of them mean the medication is failing you

And injecting into tissue that is already inflamed from a recent injection