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Oxidized LDL cholesterol can trigger mast cells.[ref][ref] Another study on mast cells and oxidized LDL: The results of this work indicate that the co-activation of macrophages and mast cells by oxLDL is an important mechanism for endothelial dysfunction and atherogenesis

The authors cited the scientific foundation provided by these studies as supporting ongoing and projected clinical trials in dermal wound repair, corneal injuries, and cardiac and CNS tissue regeneration

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There are no major side effects reported, though patients can experience diarrhea and swelling or redness at the injection site

Indeed, overactivation of PARPs with resulting severe depletion of NAD+ has been highlighted recently by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), which is found to severely deplete cellular NAD+ due to overactivation of PARPs

This finding suggests the body does not recognize AOD9604 as a foreign substance