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Ipamorelin may increase appetite due to its action on the ghrelin receptor, which is known to stimulate hunger

Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U

Therefore, DPP-4 inhibitors may theoretically reduce the production of PYY(3-36), which could partially offset the benefits brought by GLP-1, such as satiety

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There, the fats are oxidized and converted into usable energy (ATP)