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The ubiquitination-26S proteasome system is a key pathway for protein degradation, involving a cascade reaction catalysed by specific enzymes: ubiquitin-activating enzyme (E1), ubiquitin-binding enzyme (E2), and ubiquitin ligase (E3), with the substrate primarily dictated by ubiquitin ligase 40,41,42

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Once you find the dose that is not creating these problems, over time your body may adjust to it and you won't have such a strong reaction

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