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Indeed, non-lytic eryptosis is considered one mechanism that ensures the elimination of erythrocytes prior to the occurrence of premature hemolysis [89, 230,231,232]

However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain

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