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While it is generally safe, melatonin is a potent hormone, originally extracted from a cows pineal gland, and it can have a number of adverse effects and drug interactions, ranging from nausea to increased blood pressure

Liu R, Meng X, Yu X, Wang G, Dong Z, Zhou Z, et al

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These substances are theorised to enhance hepatic fat metabolism and support liver function

To avoid anesthetic complications, patients may be advised to discontinue semaglutide or GLP agonists a week before surgery, or they may need to have an ultrasound to check the contents of their stomach before anesthesia is administered

But it does so indirectly, and that distinction is everything