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[3] [4] Pharmacokinetically, oral letrozole is rapidly absorbed with bioavailability exceeding 99%, reaches peak plasma concentrations within 1-2 h, displays extensive tissue distribution, exhibits minimal protein binding, and shows a terminal half-life of roughly 42 h, allowing once-daily dosing

International Journal of Molecular Sciences, 25(3), 1459 .

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Current findings are derived primarily from preclinical and experimental research settings

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However, both medications can cause gastrointestinal side effects such as nausea, vomiting, or diarrhea, which may be intensified when taken together