While the majority of side effects so far reported to the MHRA for tirzepatide and semaglutide are non-serious 22 , there are growing warnings about serious conditions, such as acute pancreatitis, associated with GLP-1 use, although studies currently remain inconclusive 25
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Despite the lack of conclusive long-term data, the management of weight should be a priority in obese patients with hypertension, given the promising results from recent studies
doi: 10.1016/j.ccc.2012.07.006 Leeming MG, Gamon LF, Wille U, et al
Phase II trial results of daily subcutaneous semaglutide in patients with metabolic dysfunction-associated steatotic liver
Disagreements between individual judgements were solved by a third author