mechanism of action for glp 1 Mechanisms and Therapeutic Application of Glucagon-like Peptide-1: Cell Metabolism Emerging Frontiers in GLP-1 Therapeutics:

Its novel mechanism allows the peptide to act as an agonist for both GLP-1 and GIP receptors

doi: 10.1016/j.diabres.2018.10.013 10 HoganAETobinAMAhernTCorriganMAGaoatsweGJacksonRet al

PMID: 33479187

Potent nootropic that promotes synaptogenesis

The importance of this protein in immune regulation is reinforced by the multiorgan inflammation reported in A20 deficient mice and the association of mutations in this enzyme with IBD (Brenchley and Douek 2012

These include liraglutide (Saxenda) and semaglutide (Wegovy), representing an expansion beyond their original diabetes indication and highlighting the broader metabolic impact of GLP-1 pathway activation