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This is particularly relevant in muscle and cardiovascular research models

Through highly sensitive detection methods, such as ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS/MS), multiple amino metabolites can be quantified simultaneously to comprehensively analyze the metabolic network of taurine and hypotaurine

Lastly, our study cohort was predominantly Caucasian and male, reflective of the population cared for within the VHA system, thus results may not be generalizable to a wider population, although some recent studies found that VHA population have similar health characteristics as individuals with other insurance coverage suggesting greater generalizability