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Several in vitro and in vivo experimental models have highlighted a decreased cholesterol synthesis in deficient G6PD cells or animals [12, 14, 49] as well as a concomitant increase in lipid peroxidation, which suggests that the impairment of the antioxidant defense prevails over the cholesterol-lowering effect [94]

doi:10.1111/jhn.12433 Rao P, Bhide P

HSP70s in autophagy In contrast to the UPS, autophagy, a lysosome-recruiting type of PQC, involves a transition of damaged proteins through biological membranes via several mechanisms

The concentration difference is not marginal

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David R