Although the exact mechanisms are not fully understood, this may be due to improved energy regulation
Possibilities include: fecal SCFA levels (as an indicator of beneficial fermentation), serum TMAO (marker of detrimental microbial metabolism), gut permeability assays (like urinary sugar tests or blood zonulin) to gauge gut barrier integrity, and even gut microbial gene profiles that might predict rapid vs slow disease progression
Most of these drugs produced by compounding pharmacies have been sold to patients via telehealth companies such as Ro, Sesame, Hims & Hers, and even Weight Watchers at a substantial discount ($200-300/month compared to the Wegovy list price of about $1,350/month). In the US, he added, We can expect at least 15 new AOM [anti-obesity medications] drugs on the market within the next five years
The STEP-1 trial (NEJM 2021) demonstrated 14.9% average weight loss with semaglutide 2.4 mg over 68 weeks
For researchers, this complexity is both exciting and challenging
For metabolic research, this has several implications
