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In fact, oxidative stress can lead to the decrease of DNA-binding activities of activator protein-1 and CREB (cyclic AMP-response element-binding protein) which is associated with the reduction of BDNF (brain-derived neurotrophic factor) gene expression, as well as oxidative stress, and can result in impairment of NMDA channel function that is related to the decrease in BDNF gene expression

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Syland E, Heier I, Rodriguez-Gallego C, et al

Additionally, levels of GPX4, an important regulator of ferroptosis, are reduced in spinal cord neurons of both MS brains and experimental autoimmune encephalomyelitis (EAE) mice, indicating that ferroptosis is an early pathological event in EAE [190]

And there are meaningful, evidence-informed approaches to addressing them

Chronic administration of these antibiotics increases the excretion of pivaloyl-carnitine, which can lead to carnitine depletion