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Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling

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Each participant had one practice trial before the recorded official measurement

These results demonstrated that the Si-based agent alleviated the visceral pain and discomfort associated with UC, as well as the symptoms of UC