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GLP-1R is expressed in the AP and nucleus of the solitary tract (NTS) located in the hindbrain, and c-Fos expression after GLP-1RA injection was apparent in hindbrain GLP-1R cells, with further studies demonstrating these cells role in mediating GLP-1RA actions [59,96,102,103]

Moreover, improved hepatocyte ballooning and steatosis, inhibited inflammatory pathways, mitophagy-mediated active pyroptosis were noticed with liraglutide use in patients with NAFLD [35,36,37]

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