SIRT2, present both in nuclear and cytoplasmic compartments, can increase MFN2 and decrease DRP1, thus promoting mitochondrial fusion 104,105
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Furthermore, rescue experiments with antioxidant N-acetylcysteine (NAC) showed that the expression of 4-HNE and the apoptosis in SGNs were significantly decreased, while the number of surviving SGNs was increased in peroxynitrite + NAC group compared the peroxynitrite-only group and in peroxynitrite + gpx1 / + NAC group vs
Vitamin C is also involved in collagen synthesis, which supports the structure and maintenance of skin, blood vessels, bones, and connective tissues
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When glutathione levels are depleteddue to stress, poor diet, toxins, infections, or agingyour body struggles to maintain internal balance