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Using the human hepatoma cell line HuH7 as a model, Leung et al

The endometriums dynamic nature arises from its responses to the oscillating ovarian hormones estradiol (E2), a form of estrogen, and progesterone (P4)which are regulated by the hypothalamic-pituitary axis

Ottawa, ON, USA: 2019

Building on the evidence of Erastin-induced cell death mentioned earlier, we posit that Erastin can restrain lesion growth in EMS by inhibiting system Xc , depleting cystine and GSH, compromising GPX4 activity, and driving lipid peroxidation within EESCs