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The absence of GEP44-mediated changes to the ISR in the absence of a Y1-R antagonist suggests two possible mechanisms that would be consistent with the serum glucose-lowering effects observed in response to this chimeric peptide in vivo

Basak D, Gamez D, Deb S

Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J (2016) Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

MT-IIs documented mucosal stability and receptor potency make it a useful model compound in sublingual delivery studies particularly for comparing systemic exposure achieved via mucosal routes against injectable reference data

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It's a master antioxidant tripeptide which is made in your cells from glutamine, cysteine and glycine